Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia
Hox homeobox transcription factors drive leukemogenesis efficiently only in the presence of Meis or Pbx proteins.Here we show that Glass Ornament Pbx3 and Meis1 need to dimerize to support Hox-induced leukemia and we analyze the molecular details of this cooperation.In the absence of Pbx3, Meis1 was highly unstable.As shown by a deletion analysis M